For depressed marks or pit-like marks, collagen injection is one choice that is used often. In this procedure, collagen is definitely injected to your skin to raise the depressed area to the same level as the surface of the original skin. It aims to smooth-out the damaged epidermis and remove the appearance of pits. In some full cases, autologous fat transfer is the process used. This calls for getting healthy skin from another area of the body to be utilized as filler for the depressed or crater-like damage.MKRN3 is an imprinted gene that’s expressed just from the paternal allele.27 All affected family inherited their mutations from their fathers, indicating best segregation in accordance with the imprinted mode of inheritance. The main one heterozygous carrier known to have inherited his mutation from his mom was unaffected, needlessly to say. The remaining 10 families didn’t have any detectable rare coding variants in MKRN3. The prevalence of truncating variants is much greater than that seen in population-based databases .