Causes: The main reason why these glands get weakened is due to continued stress coupled with poor nutrition. Great negative feelings like anger, fear, worry, anxiety, major depression and guilt can result in exhaustion. Additional behavioral patterns like overworking, extreme physical or mental strain, over exercise, and deprived sleep or sleeping very late during the night could be the other notable causes of adrenal fatigue. Thus it is crucial to start the healing up process by initial strengthening the glands. Eating on time, eating healthy, proper relaxation, proper diet and exercise and good dietary and mineral health supplements can relieve one out of this illness. Those experiencing surgery, injury or traumatic conditions may have got the adrenaline glands affected also.For details of the analysis design and statistical evaluation plan, see the study process, available with the full text of this article at NEJM.org. The scholarly study was approved by the medical ethics committee of University INFIRMARY Utrecht. There was no commercial involvement in the trial. Patients Children 1 to 10 years old with symptoms of tympanostomy-tube otorrhea that had lasted for 7 days at the time of screening were eligible for trial participation. We excluded children with a body’s temperature of more than 38. We also excluded kids with Down’s syndrome, a craniofacial anomaly, a known immunodeficiency, or an allergy to the medications found in this study.